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A research team from Lawrence Berkeley National Laboratory and the University of California (USA) conducted experiments transforming bacteria to create new natural carbon products. This is a new step towards developing sustainable biochemistry.

This advance is demonstrated in the use of bacteria to combine natural enzymatic reactions with a new reaction called the carbene transfer reaction. This will be a solution to help reduce industrial emissions in the future as it provides a sustainable alternative to chemical manufacturing processes that often rely on fossil fuels.


Professor Jay Keslin – Executive Director of the Joint Bioenergy Institute (JBEI) of the US Department of Energy, said that the research team was able to synthesize everything in this reaction inside bacterial cells, from natural enzymes to carbene (research published in Nature*). Just add sugar and the cells will do the rest. Carbene is a highly reactive carbon-based chemical molecule that can be used in many different types of reactions. For decades, scientists have hoped to use the carbene reaction to produce fuels and chemicals, as well as discover and synthesize drugs. However, these carbene processes can only be performed in small quantities through a test tube and require expensive chemicals to drive the reaction.

In this new study, researchers replaced expensive chemicals with natural products that can be produced by strains of Streptomyces bacteria. Because bacteria use sugars to create chemical products through cellular metabolism, the process is more environmentally friendly than the way chemicals are commonly used today. The researchers observed the bacteria converting sugars into carbenee precursors and olefin substrates. The bacteria also metabolize P450 enzymes to produce cyclopropane – a high-energy molecule that has the potential to be used for the sustainable production of new bioactive compounds and advanced biofuels.

However, according to Berkeley Lab postdoctoral fellow Jing Huang, although the system is fully functional and can be used in large numbers, it is not yet ready for commercialization. . However, with the positive results of the research, this will be an important step forward in the development of green biochemistry.

According to Moitruongvadothi.vn

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